葛东亮 教授 生物医学工程

92673

葛东亮

教授

生物医学工程创新中心

E-mail: gedl@sustc.edu.cn


 南方科技大学创新创业学院教授,美国硅谷Apostle 公司及中国南方科技大学-Apostle联合产业项目董事长。葛博士主攻方向为精准医疗、基因组学大数据及其临床应用。葛博士于2009年被美国基因组科技杂志命名为“科技新星”;2015年被英国Phacilitate 机构命名为“全球对生物医药大数据最具影响力50人”。截至目前,他共发表学术论文70余篇,被引用17000多次,其中在英国Nature杂志发表5篇,在美国Science杂志发表1篇,Nature子刊若干篇。葛博士是多项技术专利的发明人。他于2009年首次发现人类IL28B DNA 变异指导临床用药疗效,该科学突破发表于英国Nature杂志,单篇文献被引用3600余次,并被成功开发为精准医疗产品,授权于美国LabCorp(LabCorp 480630)及Quest Diagnostics (AccuType® IL28B)公司上市; 并被美国药品及食品监督管理局(U.S. FDA)引入工业界指南。葛博士2004年毕业于中国协和医科大学及中国医学科学院,取得博士学位;2005年赴美于佐治亚医学院、美国杜克大学接受博士后训练,之后担任美国杜克大学Duke University助理教授职位;受邀为美国国立卫生研究院项目评审委员会委员。 葛博士拥有中美两地企业的领导经验,在 美国硅谷创立Apostle公司,入选2018北美生物科技新锐20强;此前,在总部位于中国南京的百家汇精准医疗控股集团有限公司担任总裁(2016-2017); 于美国加州硅谷吉利德科学公司(Gilead Sciences)研发部门任总监 (2011-2016),在该公司负责生物信息学与基因组学、精准医疗策略的基础设施、人员、项目、预算、科学的战略领导,期间参与了全球领先的抗丙型肝炎药物索菲布韦片(Sofosbuvir)等的临床开发。索菲布韦片在人类历史上首次实现95%以上治愈人类慢性丙型肝炎感染,年销售额达到190亿美元。


研究方向

 葛东亮教授的研究方向是研发革命性的新型基因组检测技术,以根本上提高使用液体活检进行疾病检测的准确性;为人类提供一种全球领先的健康管理和癌症筛查技术方法, 从而使得早期、高效的外科和其他临床干预成为可能。这一方向可以应用于广阔的医疗大健康领域,包括无创产前诊断 NIPT、感染性疾病、药物研发等。 液态活检技术是一种检测人类体液,包括血液、尿液、脑脊液等中的游离核酸,以实现疾病的诊断、监测和预后等的新型技术。 液态活检技术可以成为疾病早期诊断的有效工具,但必须对其进行准确、灵敏、有效力的检测。液态活检技术的发展和技术衍生,未来5-20年,将对人类对抗癌症,产生一个革命性、摧枯拉朽的科学和产业影响。 葛教授团队课题组的研究方向是研发、应用革命性的新型基因组检测技术和计算机分析技术,以根本上解决基因组检测临床应用中的一些关键挑战,从而提高全球人类大健康状况。未来的科研工作开展计划,具体可以分为三个层面:

(1)若干种新型的化学和生物化学材料和方法,以实现人类血浆、血清、唾液、尿液、脑脊液等体液中微量遗传物质的高效率富集、保存、抽提、靶向操作等,作为平台性技术可以应用于广阔的遗传物质分析领域。

(2)肿瘤大数据平台和人工智能机器学习技术,确保准确高效地从高质量肿瘤基因组大数据进行深度机器学习,有效地解决肿瘤基因组高度异质性的问题。基于人工智能技术,我们可以精准识别样本中的循环肿瘤DNA,进而实现早期癌症的诊断。

(3)上述化学和生物化学材料和方法和人工智能机器学习技术的有机融合。 目的是实现样本中肿瘤DNA片段的精准、高效富集,并对这些DNA片段进行精准分析,用于早期癌症的诊断。该技术融合后,与传统血浆游离DNA富集技术相比,可以特异性地富集肿瘤DNA,去除来自于正常组织的DNA片段背景噪音,提高了肿瘤DNA分析的准确性,并降低测序深度及成本,使得高准确度、低成本的癌症早期诊断成为可能。


代表性论文和专利

[1]      Ge D*, Fellay J*, Thompson AJ*, Simon JS*, Shianna KV, Urban TJ, Heinzen EL, Qiu P, Bertelsen AH, Muir AJ, Sulkowski M, McHutchison JG, Goldstein DB. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 2009:461, 399-401.

      · 《自然》新闻专访: Genomics: Hepatitis C virus gets personal. Nature 2009; 461 (357-358).

      · 《自然》 展望: Pharmacogenomics: playing the odds. Nature. 2011;474(7350):S9-10.

      · 专利授权产品: LabCorp Inc.; Quest Diagnostics Inc.

      · 引用数: 超3000次

      · Ranked No. 7 across all scientific areas published by Nature (Google Scholar Metrics)

[2]      Fellay J*, Thompson AJ*, Ge D*, Gumbs CE, Urban TJ, Shianna KV, et al. ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C. Nature. 2010;464(7287):405-8. (* Equal authors) {Fellay, 2010 #320}

[3]      Thomas DL, Thio CL, Martin MP, Qi Y, Ge D, O'hUigin C, Kidd J, Kidd K, Khakoo SI, Alexander G, Goedert JJ, Kirk GD, Donfield SM, Rosen HR, Tobler LH, Busch MP, McHutchison JG, Goldstein DB, Carrington M. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature 2009461, 798-801.

[4]      Stefansson H, Ophoff RA, Steinberg S, Andreassen OA, Cichon S, Rujescu D, Werge T, Pietilainen OP, Mors O, Mortensen PB, Sigurdsson E, Gustafsson O, Nyegaard M, Tuulio-Henriksson A, Ingason A, Hansen T, Suvisaari J, Lonnqvist J, Paunio T, Borglum AD, Hartmann A, Fink-Jensen A, Nordentoft M, Hougaard D, Norgaard-Pedersen B, Bottcher Y, Olesen J, Breuer R, Moller HJ, Giegling I, Rasmussen HB, Timm S, Mattheisen M, Bitter I, Rethelyi JM, Magnusdottir BB, Sigmundsson T, Olason P, Masson G, Gulcher JR, Haraldsson M, Fossdal R, Thorgeirsson TE, Thorsteinsdottir U, Ruggeri M, Tosato S, Franke B, Strengman E, Kiemeney LA, Group, Melle I, Djurovic S, Abramova L, Kaleda V, Sanjuan J, de Frutos R, Bramon E, Vassos E, Fraser G, Ettinger U, Picchioni M, Walker N, Toulopoulou T, Need AC, Ge D, Lim Yoon J, Shianna KV, Freimer NB, Cantor RM, Murray R, Kong A, Golimbet V, Carracedo A, Arango C, Costas J, Jonsson EG, Terenius L, Agartz I, Petursson H, Nothen MM, Rietschel M, Matthews PM, Muglia P, Peltonen L, St Clair D, Goldstein DB, Stefansson K, Collier DA, Kahn RS, Linszen DH, van Os J, Wiersma D, Bruggeman R, Cahn W, de Haan L, Krabbendam L, Myin-Germeys I. Common variants conferring risk of schizophrenia. Nature 2009:460(7256):744-7.

[5]      Stefansson H, Rujescu D, Cichon S, Pietilainen OP, Ingason A, Steinberg S, Fossdal R, Sigurdsson E, Sigmundsson T, Buizer-Voskamp JE, Hansen T, Jakobsen KD, Muglia P, Francks C, Matthews PM, Gylfason A, Halldorsson BV, Gudbjartsson D, Thorgeirsson TE, Sigurdsson A, Jonasdottir A, Jonasdottir A, Bjornsson A, Mattiasdottir S, Blondal T, Haraldsson M, Magnusdottir BB, Giegling I, Moller HJ, Hartmann A, Shianna KV, Ge D , Need AC, Crombie C, Fraser G, Walker N, Lonnqvist J, Suvisaari J, Tuulio-Henriksson A, Paunio T, Toulopoulou T, Bramon E, Di Forti M, Murray R, Ruggeri M, Vassos E, Tosato S, Walshe M, Li T, Vasilescu C, Muhleisen TW, Wang AG, Ullum H, Djurovic S, Melle I, Olesen J, Kiemeney LA, Franke B, Kahn RS, Linszen D, van Os J, Wiersma D, Bruggeman R, Cahn W, Germeys I, de Haan L, Krabbendam L, Sabatti C, Freimer NB, Gulcher JR, Thorsteinsdottir U, Kong A, Andreassen OA, Ophoff RA, Georgi A, Rietschel M, Werge T, Petursson H, Goldstein DB, Nothen MM, Peltonen L, Collier DA, St Clair D, Stefansson K. Large recurrent microdeletions associated with schizophrenia. Nature . 2008;455(7210):232-6.

[6]      Fellay J, Shianna KV *,Ge D *, Colombo S *, Ledergerber B *, Weale M *, Zhang K, Gumbs C, Castagna A, Cossarizza A, Cozzi-Lepri A, De Luca A, Easterbrook P, Francioli P, Mallal S, Martinez-Picado J, Miro JM, Obel N, Smith JP, Wyniger J, Descombes P, Antonarakis SE, Letvin NL, McMichael AJ, Haynes BF, Telenti A, Goldstein DB. A whole-genome association study of major determinants for host control of HIV-1. Science . 2007;317(5840):944-7. (* Equal authors) (Citations: 390).

[7]      Thomas R, Apps R, Qi Y, Gao X, Male V, O'HUigin C, O'Connor G, Ge Det al. HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C. Nat Genet. 2009;41(12):1290-4.

[8]      Ge D, Ruzzo EK, Shianna KV, He M, Pelak K, Heinzen EL, Need AC, Cirulli ET, Maia JM, Zhu M, Singh A, Allen AS, Goldstein DB. SVA: Software for Annotating and Visualizing Sequenced Human Genomes. Bioinformatics2011;27(14):1998-2000. (software: http://www.svaproject.org ).

[9]      Zhu Q *, Ge D*, Maia JM, Zhu M, Petrovski S, Dickson SP, Heinzen EL, Shianna KV, Goldstein DB. A Genome-Wide Comparison of the Functional Properties of Rare and Common Genetic Variants in Humans. American Journal of Human Genetics. 2011;88(4):458-68.

[10]      Nelson D, Yoshida EM, Paulson MS, Hengen MS, Hengen PN, Ge D, Kanwar B, McNally J, Pang PS, Subramanian GM, McHutchison JG, Urbanek P, Lawitz E, Urban TJ. Genome-wide association study to characterize serum bilirubin elevations in patients with HCV treated with GS-9256, an HCV NS3 serine protease inhibitor.  Antiviral Therapy. 2014 Feb 6. doi: 10.3851/IMP2747. [Epub ahead of print].

[11]      Pelak K*, Shianna KV*, Ge D*, Maia JM, Zhu M, Smith JP, et al. The characterization of twenty sequenced human genomes. PLoS Genet. 2010;6(9): e1001111. 

[12]      Sobreira NLM, Cirulli ET, Avramopoulos D, Wohler E, Oswald GL, Stevens EL, Ge D, et al. Whole-Genome Sequencing of a Single Proband Together with Linkage Analysis Identifies a Mendelian Disease Gene. PLoS Genet 2010;6(6):e1000991.

[13]      Todd J, Goldstein DB, Ge D, Christie J, Palmer, SM. The State of Genome-Wide Association Studies in Pulmonary Disease: A New Perspective. American Journal of Respiratory and Critical Care Medicine. 2011. In press. 

[14]      Thompson AJ, Muir AJ, Sulkowski MS, Patel K, Tillmann HL, Clark PJ, Naggie S, Fellay J, Ge D, McCarthy JJ et al: Hepatitis C trials that combine investigational agents with pegylated interferon should be stratified by interleukin-28B genotype. Hepatology 2010, 52(6):2243-2244.

[15]      Thompson AJ, Clark PJ, Singh A, Ge D, et al. Genome-wide association study of interferon-related cytopenia in chronic hepatitis C patients. J Hepatol. 2011.

[16]      Thompson AJ, Fellay J, Patel K, Tillmann HL, Naggie S, Ge D, et al. Variants in the ITPA Gene Protect Against Ribavirin-Induced Hemolytic Anemia and Decrease the Need for Ribavirin Dose Reduction. Gastroenterology. 2010;139(4):1181-9.

[17]      Thompson AJ, Muir AJ, Sulkowski MS, Ge D, et al. Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus. Gastroenterology. 2010;139(1):120-9 e18.

[18]      Walley NM, Julg B, Dickson SP, Fellay J, Ge D, Walker BD, Carrington M, Cohen MS, de Bakker PI, Goldstein DB, Shianna KV, Haynes BF, Letvin NL, McMichael AJ, Michael NL, Weintrob AC. The Duffy antigen receptor for chemokines null promoter variant does not influence HIV-1 acquisition or disease progression. Cell Host Microbe 2009; 5 (5) : 408-10.

[19]      Need AC, Attix DK, McEvoy JM, Cirulli ET, Linney KL, Hunt P, Ge D, Heinzen EL, Maia JM, Shianna KV, Weale ME, Cherkas LF, Clement G, Spector TD, Gibson G, Goldstein DB. A Genome-wide Study of Common SNPs and CNVs in Cognitive Performance in the CANTAB battery. Hum Mol Genet 2009.

[20]    Pillai SG, Ge D *, Zhu G*, Kong X*, Shianna KV, Need AC, S. F, Hersh CP, Bakkgators, Rennard SI, Lomas D, Silverman EK, Goldstein DB. A Genome-wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of two Major Susceptibility Loci. PLoS Genet . 2009; 5(3): e1000421. doi:10.1371/journal.pgen.1000421 (* Equal authors).

[21]    Need AC *, Ge D * , Maia J, Shianna KV, Feng S, Strittmatter WJ, McEvoy JP, Keefe RSE, St Jean PL, Giegling I, Hartmann AM, M?ller H, Ruppert A, Fraser G, Crombie C, Francks C, St.Clair D, Roses AD, Muglia P, Rujescu D, Goldstein DB. A Genome-Wide Investigation of SNPs and CNVs in Schizophrenia. PLoS Genet. 2009; 5(2):e1000373.(* Equal authors).

[22]    Heinzen E *, Ge D *, Cronin KD, Maia J, Shianna KV, Gabriel W, Welsh-Bohmer KA, Hulette CM, Denny T, Goldstein DB. Tissue specific genetic control of gene expression and alternative splicing: Implications for the study of human complex traits. PLoS Biol . 2008; 6(12): e1000001. (* Equal authors).

[23]    Ge D , Zhang K, Need AC, Martin O, Fellay J, Urban TJ, Telenti A, Goldstein DB. WGAViewer: Software for genomic annotation of whole genome association studies. Genome Research. 2008;18(4):640-3. (citations: 87).

[24]    Price AL, Weale ME, Patterson N, Myers SR, Need AC, Shianna KV, Ge D , Rotter JI, Torres E, Taylor KD, Goldstein DB, Reich D. Long-range LD can confound genome scans in admixed populations. Am J Hum Genet 2008 . 83(1):132-5.

[25]   Cavalleri GL, Weale ME, Shianna KV, Singh R, Lynch JM, Grinton B, Szoeke C, Murphy K, Kinirons P, O'Rourke D, Ge D , Depondt C, Claeys KG, Pandolfo M, Gumbs C, Walley N, McNamara J, Mulley JC, Linney KN, Sheffield LJ, Radtke RA, Tate SK, Chissoe SL, Gibson RA, Hosford D, Stanton A, Graves TD, Hanna MG, Eriksson K, Kantanen AM, Kalviainen R, O'Brien TJ, Sander JW, Duncan JS, Scheffer IE, Berkovic SF, Wood NW, Doherty CP, Delanty N, Sisodiya SM, Goldstein DB. Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study. Lancet Neurol. 2007;6(11):970-80.

[26]    Valdes AM, Loughlin J, Timms KM, van Meurs JJ, Southam L, Wilson SG, Doherty S, Lories RJ, Luyten FP, Gutin A, Abkevich V, Ge D, Hofman A, Uitterlinden AG, Hart DJ, Zhang F, Zhai G, Egli RJ, Doherty M, Lanchbury J, Spector TD. Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis. Am J Hum Genet 2008;82(6):1231-40.

[27]    Cronin KD, Ge D, Manninger P, Linnertz C, Rossoshek A, Orrison BM, Bernard DJ, El-Agnaf OM, Schlossmacher MG, Nussbaum RL, Chiba-Falek O. Expansion of the Parkinson Disease-Associated SNCA-Rep1 Allele Up-Regulates Human {alpha}-Synuclein in Transgenic Mouse Brain. Hum Mol Genet 2009.

[28]    Need AC, Keefe RS, Ge D, Grossman I, Dickson S, McEvoy JP, Goldstein DB. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. Eur J Hum Genet 2009; 17 (7) : 946-57 .

[29]    Ge D , Su S, Zhu H, Dong Y, Wang X, Harshfield GA, Treiber FA, Snieder H. Stress-Induced Sodium Excretion. A New Intermediate Phenotype to Study the Early Genetic Etiology of Hypertension? Hypertension 2009;53:262-269

[30]    Ge D , Gooljar SB, Kyriakou T, Collins LJ, Swaminathan R, Snieder H, Spector TD, O'Dell SD. Association of Common JAK2 Variants With Body Fat, Insulin Sensitivity and Lipid Profile. Obesity (Silver Spring) 2008;16(2) : 492-6.

[31]    Ge D, Zhu H, Huang Y, Treiber FA, Harshfield GA, Snieder H, Dong Y. Multilocus analyses of Renin-Angiotensin-aldosterone system gene variants on blood pressure at rest and during behavioral stress in young normotensive subjects. Hypertension . 2007 ;49(1):107-12.

[32]     Ge D, Young TW, Wang X, Kapuku GK, Treiber FA, Snieder H. Heritability of arterial stiffness in black and white American youth and young adults. Am J Hypertens 2007;20(10) : 1065-72.

[33]    Kapuku GK, Ge D, Vemulapalli S, Harshfield GA, Treiber FA, Snieder H. Change of genetic determinants of left ventricular structure in adolescence: longitudinal evidence from the Georgia cardiovascular twin study. Am J Hypertens 2008;21(7):799-805.

[34]    Oberg S, Ge D, Cnattingius S, Svensson A, Treiber FA, Snieder H, Iliadou A. Ethnic differences in the association of birth weight and blood pressure the georgia cardiovascular twin study. Am J Hypertens 2007;20(12):1235-41.

[35]    Zhu H, Yan W, Ge D , Treiber FA, Harshfield GA, Kapuku G, Snieder H, Dong Y. Relationships of cardiovascular phenotypes with healthy weight, at risk of overweight, and overweight in US youths. Pediatrics 2008;121(1) : 115-22.

[36]    Wang L, Li B, Lu X, Zhao Q, Li Y, Ge D, Li H, Zhang P, Chen S, Chen R, Qiang B, Gu D. A functional intronic variant in tyrosine hydroxylase (TH) gene confers risk of essential hypertension in northern Chinese Han population. Clin Sci (Lond) 2008.

[37]    Dalageorgou C, Ge D , Jamshidi Y, Nolte IM, Riese H, Savelieva I, Carter ND, Spector TD, Snieder H. Heritability of QT Interval: How Much Is Explained by Genes for Resting Heart Rate? J Cardiovasc Electrophysiol 2007.

[38]    Morell RJ, Brewer CC, Ge D , Snieder H, Zalewski CK, King KA, Drayna D, Friedman TB. A twin study of auditory processing indicates that dichotic listening ability is a strongly heritable trait. Hum Genet 2007;122(1):103-11.

[39]   Zhu H, Yan W, Ge D, Treiber FA, Harshfield GA, Kapuku G, Snieder H, Dong Y. Cardiovascular characteristics in American youth with prehypertension. Am J Hypertens 2007;20(10):1051-7.

[40]    Jamshidi Y, Snieder H, Ge D , Spector TD, O'Dell SD. The SH2B gene is associated with serum leptin and body fat in normal female twins. Obesity (Silver Spring) . 2007;15(1):5-9.

[41]    Healey PR, Mitchell P, Gilbert CE, Lee AJ, Ge D , Snieder H, Spector TD, Hammond CJ. The inheritance of peripapillary atrophy. Invest Ophthalmol Vis Sci 2007;48(6):2529-34.

[42]    Weili Y, He B, Yao H, Dai J, Cui J, Ge D , Zheng Y, Li L, Guo Y, Xiao K, Fu X, Ma D. Waist-to-height ratio is an accurate and easier index for evaluating obesity in children and adolescents. Obesity (Silver Spring) 2007;15(3):748-52.

[43]    Jamshidi Y, Gooljar SB, Snieder H, Wang X, Ge D , Swaminathan R, Spector TD, O'Dell SD. SHP-2 and PI3-kinase genes PTPN11 and PIK3R1 may influence serum apoB and LDL cholesterol levels in normal women. Atherosclerosis 2007; 194 (2) : e26-33

[44]    Ge D, Dong Y, Wang X, Treiber FA, Snieder H. The Georgia Cardiovascular Twin Study: influence of genetic predisposition and chronic stress on risk for cardiovascular disease and type 2 diabetes.

[45]    Twin Res Hum Genet . 2006;9(6):965-70.

[46]    Spencer-Jones NJ*, Ge D *, Snieder H, Perks U, Swaminathan R, Spector TD, Carter ND, O'Dell SD. AMP-kinase alpha2 subunit gene PRKAA2 variants are associated with total cholesterol, low-density lipoprotein-cholesterol and high-density lipoprotein-cholesterol in normal women. Journal of Medical Genetics. 2006 ;43(12):936-42. (* Joint authors.)

[47]    Gu D, Ge D, Snieder H, He J, Chen S, Huang J, Li B, Chen R, Qiang B. Association of alpha-1A adrenergic receptor gene variants on chromosome 8p21 with human stage-2 hypertension. Journal of Hypertension , 2006;24(6):1057-1064.

[48]    Kupper N, Ge D, Treiber FA, Snieder H . Tracking of blood pressure and underlying hemodynamics in European and African American adolescents. Stable heritabilities and expression of new genes. Hypertension , 2006 47(5):948-54 .

[49]    Gu D, Su S, Ge D, Chen S, Huang J, Li B, Chen R, Qiang B. An Association Study with 33 SNPs in 11 Candidate Genes for Hypertension in Chinese. Hypertension , 2006;47(6):1147-54.

[50]    Herold SE, Young TW, Ge D, Snieder H, Lovrekovic GZ. Sleep Disordered Breathing in Pediatric Patients with Tetralogy of Fallot. Pediatric Cardiology , 2006;27(2):243-9.

[51]    de Lange M, Andrew T, Snieder H, Ge D, Futers TS, Standeven K, Spector TD, Grant PJ and Ariens RAS. Joint linkage and association of 6 single nucleotide polymorphisms in the factor XIII-A subunit gene point to V34L as the main functional locus. Arteriosclerosis, Thrombosis, and Vascular Biology . 2006 Aug;26(8):1914-9.

[52]    Yang W, Huang J, Yao C, Su S, Liu D, Ge D , Gu D. Linkage and linkage disequilibrium analysis of the lipoprotein lipase gene with lipid profiles in Chinese hypertensive families. Clinical Science (Lond). 2005;108(2):137-142.

[53]    Ge D, Huang J, Yang W, Zhao J, Shen Y, Qiang B, Gu D. Linkage analysis of chromosome 1 with essential hypertension and blood pressure quantitative traits in Chinese families. Annals of Human Genetics . 2005;69(Pt 1):45-54.

[54]    Ge D , Huang J, He J, Li B, Duan X, Chen R, Gu D. beta2-Adrenergic receptor gene variations associated with stage-2 hypertension in northern Han Chinese. Annals of Human Genetics . 2005;69(Pt 1):36-44.

[55]    Li B, Ge D , Wang Y, Zhao W, Zhou X, Gu D, Chen R. G Protein beta3 Subunit Gene Variants and Essential Hypertension in the Northern Chinese Han Population. Annals of Human Genetics . 2005;69(Pt 4):468-473.

[56]    Chen S, Yan W, Huang J, Ge D, Yao Z, Gu D. Association analysis of the variant in the regulatory subunit of phosphoinositide 3-kinase (p85alpha) with Type 2 diabetes mellitus and hypertension in the Chinese Han population. Diabetic Medicine . 2005;22(6):737-743.

[57]    Yan W, Yang X, Zheng Y, Ge D , Zhang Y, Shan Z , Simu H , Sukerobai M , Wang R . The Metabolic Syndrome in Uygur and Kazak Population. Diabetes Care . 28(10):2554-5, 2005.

[58]    Zhou X, Huang J, Chen J, Zhao J, Ge D , Yang W, Gu D. Genetic association analysis of myocardial infarction with thrombospondin-1 N700S variant in a Chinese population. Thrombosis Research . 2004;113(3-4):181-186.

[59]    Gu D, Ge D , He J, Li B, Chen J, Liu D, Chen J, Chen R. Haplotypic analyses of the aldosterone synthase gene CYP11B2 associated with stage-2 hypertension in northern Han Chinese. Clinical Genetics . 2004;66(5):409-416.

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